DEEP BLUE SEA: Hemorrhage

ANOTHER GUFFAW MOMENT FROM DEEP BLUE SEA

McCallister (Saffron Burrows) extracting brain protein from her super-shark.

One of the super sharks is annoyed at having her brains picked (literally) by Dr. McCallister, or perhaps she doesn't like second-hand smoke. In any case the shark awakens from her tranquilizer-induced slumber (while still in the lab) and bites off Jim Whitlock's hand which happens to be holding a cigarette. Tobacco is more dangerous than we knew!

Jim's arm is off. He is bleeding copiously, which looks great onscreen. His colleague, Janice Higgins, is ineffectually trying to mop up the blood gushing out of what's left of his upper extremity. This team of scientists get Jim in a gurney and rush him into an elevator. 

Janice (Jacqueline McKenzie) does a horrible first aid job for Jim (Stellan Skarsgard).
Nice blood splatters!

In the elevator crazy Dr. McCallister gives Jim a shot of something and then says, "Oh no! He's starting to hemorrhage!" "Starting" too?!?! 

What is hemorrhaging? Bleeding. That's it. Could be inside your body as with a stroke or a bruise, or it could be that you are bleeding out of your body because you scraped a knee or a super-shark bit off your arm. "Starting too..." Haw!

Later in the elevator McCallister expresses concern that she's not doing enough because she's "not that kind of doctor(1)." Russell Franklin (Samuel L. Jackson), the project's investor and the only character with the wherewithal to apply a tourniquet, tells her it's okay. 

1. To be fair, I'm not that kind of a doctor either. Oh wait... I'm not any kind of doctor. But I do know how to apply pressure to profusely bleeding sites on the body.

DEEP BLUE SEA: Alzheimer's Disease 2

LET'S START WITH THE FOOTNOTES
For an excellent overview of Alzheimer's disease visit the Alzheimer's Association. Practically everything I talk about here can be found at their site or through their links, or via Merck online.

A brain scan of the super brain of a super shark.

WHERE WAS I?
Oh yes! That crazy b---- Dr. McCallister was trying to cure that crazy b---- of a disease, Alzheimer's, by genetically engineering sharks so that they grow larger brains (which makes them intelligent as a "side effect") and thereby making it easier to harvest some unnamed shark brain protein. By bathing "inactive" human brain cells with shark brain protein, they will "reactivate" and voila! Dr. McCallister will "end all that suffering with a single pill." I laughed so hard I scared the cats.


First of all, I don't know how brain cells are "inactive" unless they're dead. So if you reactivate inactive brain cells, does that mean the patient becomes a zombie? Are their clinical tests to determine normal zombie behavior as opposed to the impaired cognition, memory, and altered behaviors of zombies with Alzheimer's?


OMG! I just googled "zombies Alzheimer's" and look what I got! This guy's got imagination!

Hunter S. Zombie's blog links the zombie virus and Alzheimer's disease.

IT'S THE DESTRUCTION, STUPID
The brain cells in a patient affected by Alzheimer's are not inactivated, but weakened and ultimately destroyed. What causes this brain cell death? Protein! (Thunderclap!) Yes, I am being silly because practically every single structure in your body (cell walls, etc.) are made of proteins. Proteins are your friends, proteins are your enemies. The same goes for shark proteins, perhaps. They can be fickle.

Beta-amyloid plaques cluster around brain cells.

Two different proteins play a role in Alzheimer's disease. Beta-amyloid fragments (from a larger protein of brain cells) start to form plagues (outside the cells) that essentially clog up the synapses between neurons, trigger inflammatory reactions, and lead to cell death, hence McCallister's inactivation. 

A brain cell (top) has tracts made from microtubules (below left),

which lose integrity when tau proteins clump (below right.)

Tau proteins help form tracts (neurofibrillary for you trivia buffs) that transport substances along the branches of the nerve cell. In Alzheimer's the tau structure is abnormal, leading to the tangling of these proteins and destruction of the tracts. The cell can no longer transport nutrients the way it should and will weaken and die.

Russell Franklin (Samuel L. Jackson) won't live long

enough to suffer from Alzheimer's.

WHAT DID THEY GET RIGHT?
The cells our intrepid scientists are experimenting with are imaged as pyramidal cells, which are indeed the cells they should be studying. The only glitch is that these cells seem to have been stained to make them easier to see with a microscope, and they appear pretty healthy, not "inactivated" by Alzheimer's.

DEEP BLUE SEA: What is Alzheimer's disease?

Deep Blue Sea: the shark's not quite that big.

I have wanted to blog about this film for a long time. Finally I will get this mother of a medical conundrum off my To Do list! Unfortunately most of the events in this film that make me love it have nothing to do with medicine or body sciences. Although, there is a particularly hilarious laugh-out-loud reference to hemorrhaging that will be discussed in a later post. And sure, when Russell Franklin (Samuel L. Jackson) gets chomped we could say the moment is about the body, but you know what I mean.   


What has driven our mad scientist Dr. Susan McCallister (Saffron Burrows) to create a bunch of shark monsters? One of the Four Spectres Of Old Age(1) - Alzheimer's Disease - that's what!

"We are this close to the reactivation of the human brain cell!"

Her father may have had Alzheimer's but Dr. McCallister is CRAZY!

WHAT A B----!
Dr. McCallister has secretly genetically engineered a race of intelligent super-sharks all for love of her father. Here's what she says to Russell Franklin:


"Have you ever known anyone with Alzheimer's?...By the end all (my father) could do was ask why my mother wasn't home. And each time I told him she was dead I had to watch him take that loss like a car wreck!"


This doctor dragged her father through emotional upheaval again and again because he suffered from an organic brain disease. What a nasty thing to do to someone! Advanced Alzheimer's patients have profound memory loss and its likely that her father forgot his grief after each re-experience of it, but c'mon! My father has advanced dementia and my mother is dead and there's NO WAY I'm going to wrench my dad's heart out on a regular schedule. That's just mean! 

Janice Higgins (Jaqueline McKenzie) tells us that sharks never

experience loss of mental function with advanced age.

Is that true? How old does a shark get, anyway?

WHAT WERE WE TALKING ABOUT?
Oh, yeah... Alzheimer's disease! What is it? Alzheimer's is a degenerative progressive brain disease causing dementia, and emotional and behavioral changes. The disease usually appears in older persons (65 and up) but there is a small percentage of people who develop the disease earlier in life. At this point there is no cure for it, but there are treatments to lessen symptoms to some degree. There are also things a patient and their friends and family can do to cope with the progressive loss of function that occurs. I speak from experience here, not just from reading the Merck Manual. If you have experience with Alzheimer's you know it's a B----!


I say this from experience too - you don't break your father's heart every time he asks about your dead mother and you don't go breeding a bunch of man-eating-super-sharks because you're feeling guilty about your father's disease!


How does Alzheimer's effect the brain (of humans, not sharks)? How can we use monster sharks to cure this disease? Stay tuned...


1. I made up that "Four Spectres Of Old Age" phrase, but I imagine them to be cancer, Parkinson's disease, osteoporosis, and Alzheimer's disease.

I AM DEEP... INTO SELF-PROMOTION

Sorry gang. Many of the movies I've been watching lately have been a bit samey and uninspiring regarding any interesting medical context, which is to say NONE. I am sure this will change soon! 

One of my gag cartoons from a performance series called Pathology Laffs!

While not blogging here I've been busy. I finished grad school at Goddard College! Cower in awe before the mighty MFA in Interdisciplinary Arts! Guess what my focus of study was? Yup! The intersection of body sciences with creative practice. This blog was one of my projects, as a matter of fact(1). 


Also, my cartoonist husband, R. Sikoryak, and I have been guest teachers at the Center for Cartoon Studies in White River Junction, VT this school year. AND I am writing and drawing a minicomic. I can't help it - EVERYONE is a cartoonist in this town! It will come out this month.


What does the rest of my life have to do with this blog? I've been distracted from The Cinematologist because I'm putting together a blog-serving-as-website documenting what I'm doing when I'm not writing about movies. If you're into body-science-themed cartooning, performance, or needlework (you heard me - needlework) you might want to check it out. You'll see I've been busy(2)...


KriotaWelt

A cross stitch of my friend Lisa's fetus.

He's even cuter as a baby!

KriotaWelt is still being built. If you didn't see that particular thing that I did that you want to see, I'll get it up there eventually.


1. The academic writing I did about this blog didn't allow for many exclamation points or slang! Sheesh!
2. I went to France, too!

CHIM CHIM CHERY #2

No worries, Mary Poppins will make Michael bathe sooner than later,

reducing the length of exposure to carcinogens.

"IT'S JUST GOOD CLEAN SOOT, MICHAEL!"
When we were last discussing chimney sweeps, Mary Poppins the movie, and scrotal cancer, I mentioned how unpredictable cancer can be. Often cancer develops years after the exposure that mutates and changes cells so that they eventually become cancerous.


That's what happens with scrotal cancer. Boys sent up those 17th and 18th century chimneys were exposed to the carcinogen (soot), later developing the cancer in adulthood(1). If they continued in the profession as men, protection from soot didn't improve just because they kept their clothes on.  English(2) sweeps of the time wore loose clothing that allowed soot to creep into all sorts of bodily crevices.  

According to Disney, loose clothing was no longer worn by chimney sweeps

such as Bert (Dick Van Dyke) and his cohorts.

How did Percival Pott(3) know to associate scrotal cancer with chimney sweeping? It's a very rare form of cancer, but it happened so frequently amongst the profession that the sweeps had a name for it - Soot Wart!


HOW DO YOU TREAT SOOT WART WHEN YOU DON'T EVEN HAVE ELECTRICITY, INDOOR PLUMBING, OR IBUPROFEN?


Onset of the warty growths usually occurs between the ages of 20 and 40. Sometimes the sweeps would just cut the "wart" out by themselves, with a knife - ouch! - and hope for the best. Without some kind of attention, the cancer could eventually spread throughout the inner thigh, invade genitals, and eventually enter the pelvic cavity. What a horrible way to die!

According to A Brief History Of Scrotal Cancer, in Pott's day, 1775, the treatment was surgery without anaesthesia, or applications of a poultice containing arsenic (another carcinogen) that would kill the warty tissue and cause the growth to slough off. Oh-my-gosh! I am grossing myself out! 

If a sweep was "as lucky as lucky can be," to quote Bert, he wouldn't have ignored the earliest stages of soot wart, sought medical attention (such as it was), and be lucky enough to be treated by a doctor/surgeon like Pott.

A carcinogenic magical wonderland of rooftops and products of combustion.

So… this winter, as you cozy up to the fire with a carcinogenic bottle of wine, and some popcorn(4), slip Mary Poppins into your DVD player (Netflix doesn’t stream it yet) and think about how lucky you are that you’re not a chimney sweep like Bert.

1. As stated in the last post, although these boys were all exposed to soot, not all of them would develop the cancer.
2. As opposed to German and other European sweeps who wore tighter clothing and had little or no incidence of scrotal cancer.
3. See CHIM CHIM CHERY #1.
4. Remind me later to talk about "Popcorn Lung".

I LOVE BAD MOVIES #4

For those of you who still enjoy reading printed ephemera, I Love Bad Movies Volume 4 presents a variety of articles discussing films from or about childhood, adolescence, and those awkward teenage years. With seventy pages of essays and a special feature interview with the director of The Children (1980), this zine makes a great read for adults fascinated or scarred by children's movies such as Troll 2, Mac and Me, and/or The Apple Dumpling Gang.

Go to page 56 and you will find my article, Hot Dogs and Parasites: Advertising Conspiracies Revealed By The Faculty. Yes, it's a long title, but I've been in grad school. What can I do? I describe the link between hotdogs, alien parasitism, and diuretics in Robert Rodriguez's movie, The Faculty. The essay was inspired by my friend Todd Alcott, who worked on the feature and made a short film about pathology and hotdogs.

BURKE AND HARE

Not quite Mary Poppins...

I LEAD A CHARMED LIFE

The luck o' the chimney sweeps must have rubbed off on me last night. It was the perfect evening! First I posted part one of my blog about Mary Poppins, chimney sweeps, and scrotal cancer in the 18th and 19th century, then I found a charming movie full of infantile humor about two criminals who's activities contributed to the creations of England's Anatomy Act of 1832.

I ask you, what is funnier that a corpse with his crotch in the air?

(Image from here.)

Which movie was this? John Landis' Burke and Hare! What fun(1)! Of course, in real life, the Williams Burke and Hare murdered 16 people(2) to sell to an Edinburgh anatomy school for dissection. If you think teachers have a hard time getting classroom supplies these days, try being an anatomist in the 19th century. There were not enough bodies of executed criminals to go around, and market demand was high.

An example of the shoddy quality of cadavers available

from grave robbers. Ick!

In the movie, Burke (Simon Pegg) and Hare (Andy Serkis) are bizarrely sympathetic. Although there are some fantastic liberties taken to develop a dynamic plot, occasionally replacing historical accuracy. The film has a number of fine moments that communicate the culture of medical education at the time.

Tim Curry (love him!) is also in the film.

There seems to be a running gag about his character and feet.

Could it be a reference to Daft Jamie, one of B and H's victims?

READ THIS BOOK

An excellent read on the history of medicine, death, poverty, and criminality in pre-20th century England is Ruth Richardson's Death, Dissection, and the Destitute. Chapter 16 focuses on our heroes Burke and Hare, but if you read all 450-odd pages, you will have an appreciation for the culture from which Burke and Hare arose as they took the profession of the Resurrectionist to its next logical incarnation. An added perk is that the movie contains a lot of visual references that can be appreciated more fully if you do a little homework.

This book is a great read! I highly recommend it.

1. It's humorous only if you think it's funny when people have the contents of chamber pots thrown on their heads, or when a barrel containing a corpse gets away from our heroes and rolls through the city streets, or if you can see the lighter side of smothering someone to death.

2. Two old men, two handicapped youths, and 12 women, according to Ruth Richardson.