Mutation - Part Three

Emma Thompson as Alice Krippin. I bet she'll be playing Hilary Clinton within ten years.

CATCH UP

Here we are in Manhattan, sometime around 2010. According to I Am Legend, Dr. Alice Krippin has developed a cure for cancer by engineering a measles virus to kill tumor cells. Unfortunately, that's not all her virus is killing!

QUARANTINE!

In the movie, and in the future, Manhattan will be closed off and quarantined. Apparently the threat of this oncolytic adenovirus of Krippin's has "gone airborne" and one way to contain it is by closing off Manhattan.

Avoid long lines! Plan your out of town trips early.

For those of you visiting our fair isle of Manhattan before any hint of this viral-mutation-ruckus starts up, just remember that there are plenty of other airborne diseases(1) floating around our delightfully efficient subway system, just waiting to be sucked up into an unwary nostril of every rat, dog, and human(2) venturing into the underworld of the MTA.

This rat took the "V" (for VIRUS) train!

UNRELIABLE EQUIPMENT PROMOTES SPREAD OF VIRUS

If we want to leave Manhattan, through an official check point, we will have our eyes screened with a device that seems to show a magnified image of the iris, displaying bleeding, or something red(3), caused by viral infection. This would not cause the hemolacria discussed in Mutation - Part Two. The detection device seems somewhat questionable in terms of its accuracy. It tests Robert Neville's wife Zoe as positive for the virus and then at the insistence of Neville, they try it again, and Zoe gets a green light (literally).

First scan indicates viral infection.

Zoe gets the green light 5 seconds later.

Faulty equipment means that we who are infected but not symptomatic should be able to get out of Manhattan with no difficulty, infecting our friends and family in Brooklyn, Queens, the Bronx, Staten Island and New Jersey. Indeed, that seems to happen. By the year 2012, there are barely any non-mutated people left in all of the world.

TAKE THAT FINGER OUT OF YOUR NOSE!

I know what you're asking yourself ... will I get the virus? Who will be the first to come down with the mutating measles? Before the virus mutates and goes airborne, nose-pickers and eye-rubbers who have virus on their fingers will be the first to be infected.

Even heads of state are not immune from this mutated virus

or the temptation to stick their finger up their nose.

Next will be people who have touched an object touched by an infected person and people who have been sneezed on or coughed on by an infected person.

Should Junior stay with Gramma, or go to nursery?

Either way, we're doomed!

This means infants, toddlers and children in day care, and people in nursing homes will get it first. As the virus mutates toddlers and old people into violent bald superhuman panting veiny photophobes, the terms "ankle biter" and "crotchety old man" will have a whole new meaning.

Wow! I'm glad no one tries to turn smallpox into a cancer cure anymore ... oh, wait! They do!

Here's the link for

the article pdf

1. Tuberculosis can float in air for at least a couple of hours. Of course tuberculosis is a bacterium and not a virus. Neither will it make you a photophobe with super-human strength.
2. In the movie, we see that rats, dogs, and people are susceptible to this virus, while deer and lions are not.
3. My understanding of eye anatomy is weak, but I believe that any kind of capillary perfusion or bleeding under the cornea or around the iris would also cause visual disturbances. Anyone care to comment?

Mutation - Part Two

VIRAL MUTATION WILL LEAD TO THE END OF HUMANKIND

Thus far, in our examination of I Am Legend, we have established how viruses find opportunity for mutation, and what types of viruses are of interest to researchers for use as oncolytic adenoviruses targeted for cancer treatments. (If that sentence makes no sense to you, go to the Mutation - Part One blog entry, March 6. Or you can just read on.)

Has anyone noticed how many movies starring

Will Smith have medical themes and show off his hunky arms?

Exercise has been clinically proven to enhance immune system function.

THE FUTURE IS NOW

As established, I Am Legend relates events that are about to ruin our lives, happening as I write this... blog! Using the film to read the future, we find that some time last year, in 2009, Doctor Alice Krippin engineered a strain of measles virus (paramyxovirus)(1) in an attempt to cure cancer. According to the film, we should expect to hear any day about Krippin's 100% cure rate for cancer by using this new viral strain in her experimental treatments.

Emma Thompson as Doctor Alice Krippin

If we are on schedule with I Am Legend, this viral cure for cancer will mutate, running horribly out of control, infecting and killing us sometime this year. It seems that this mutated virus has an infection rate between 90 and 100%, depending on your statistical source.

According to Wikipedia, once infected 90% of us will die, 8% will turn into a horribly degenerated vestige of mankind, and 2% are not affected at all, but will be murdered by mutated humans.

Mutant human attempting to murder the uninfected (talk about mood swings!)

So the brilliance of I Am Legend is that the virus used to cure cancer not only mutates its own DNA as it gets out of control and "goes airborne," but also mutates the DNA of the human host. Our entire scenario is a double mutation! For you trivia buffs, run-of-the-mill measles virus is already "airborne."

Spring colors (like blue) are all the rage this

season for the raging pandemic!

According to the movie, at any moment in 2010, we will begin to feel the initial signs and symptoms of viral infection. Many viral infections start in the same exact way, regardless of whether they are lethal, or mutating, or not. Influenza, HIV and polio all start with fever, headache, body aches, malaise. This pattern is commonly described as "flu-like symptoms."

This woman has signs of infection

with a horrible mutating epidemic,

or maybe it's the flu.

But because this is a mutated measles virus, hacking cough, sore throat and runny nose should develop tout suite, or it could just be H1N1(link for photo below.)

Oh my gosh! She sneezed! It's going airborne!

It is not clear if people infected with the mutant virus get a rash like measles,

A measles rash on the back, from an informative

article in the New York Times.

but they do develop a permanent fever (possibly as a result of the mutated adenovirus' hyper-stimulation of the body's immune response) and an accelerated metabolism...

Monitoring metabolism in the film.

...and photophobia, just like measles. I should point out that photophobia affiliated with measles infection does not make the patient's skin smoke and burn.

Double mutation induced photophobia is due to strike

the New York area in 2012 or sooner. Note the smoking epidermis.

People infected by the mutant virus also go on to lose all their hair except for eyelashes, have increased muscular power(2), increased coordination, and display behavioral changes and mood swings.

Patients may be prone to violent outbursts.

Their pets may also experience mood swings.

There also seems to be a bleeding eye thing that presents itself as a sign of infection with the virus. This bleeding eye event should not be confused with the hemolacria experienced by the character Le Chiffre in Casino Royale (blog entry CASINO ROeYeALE).

Infection with Krippin's mutated paramyxovirus

leads to bleeding from the eyes. Now we know it's not H1N1.

Le Chiffre may be infected with evil, but this is

not the result of his hemolacria.

Next time we will track the spread of this virus through the general population.

1. Paramyxoviruses are a group of viruses that cause upper respiratory illnesses like measles, mumps. These are airborne viruses. According to Wikipedia, from Greek para-, beyond, -myxo-, mucus or slime, plus virus, from Latin poison, slime. Ick!

2. Enhanced muscular endurance is not documented in the film.

SMORGASBORG #7: Endoskeletons part B

What do Sam Worthington, Peter Weller, and Will Smith have in common? They're all dreamy, and they all play characters in movies who have devices implanted into their bodies. In their films the only issues they seem to have with their artificial parts are emotional ones, but putting a foreign object into a human body without adverse physical effects is actually pretty hard to do.

Marcus.

Note the chiseled endoskeletal cheekbones.

Marcus (Worthington) in Terminator Salvation, is apparently the lone humanoid organism to have survived Skynet's experimentation to build a cyborg with a metallic endoskeleton. Why would this be so hard? (Other than the fact that a machine dominated society using humans as lab rats wouldn't really care that much if there were a lot of casualties.) Living tissue and many types of metals have problems getting along together.

YOU PUT WHAT, WHERE?

Metals for making cyborgs, or hip or knee replacements, have to be corrosion resistant and biocompatible. If you have an allergy to nickel, you sure don't want a nickel implant, or a nickel belt buckle, or a phone with nickel in it.

The consequences of nickel allergies.

Metals shed ions. In order for the body to tolerate the metal well, it can't leach too much into the surrounding tissue. Although your body uses some metals for metabolism (copper, iron, magnesium, etc.), too much can cause toxicity. You don't want that metal plate in your head shedding too much of anything near your brain(1).

So you can imagine that corrosion resistant types of metals, plastics, or ceramics, would be a good idea. Using incompatible metals could interfere with normal tissue growth near the implant(2). Blood acidity and ph balance can have a corrosive effect on metals. If metals shed into the bloodstream, your whole body may have a (systemic) reaction. Organs that filter blood, like the liver and kidneys may accumulate unhealthy amounts of metal ions, which is bad. And don't forget cancer! You have to be careful that whatever you're implanting isn't carcinogenic 20 years after you've implanted it.

Cobalt-chromium alloys, stainless steel, and titanium have been reported to have minimal tissue reactions in rabbits, dogs, and people. If Terminator Salvation was going to be really accurate, we should have seen some rabbit cyborgs hopping around killing humans.

Kelli Doyle's Cyborg-Bunny puppet

Although there are always many things to consider, many people enjoy their artificial joints (made of plastics and metals) or eye lenses (plastics), or boobs (silicone) and never have any problems. 300,000 women per year receiving breast implants can't be all wrong, can they(3)?

Lens implant

CYBORG FATIGUE

Once you find biocompatible materials to implant in the body, you also want them to last. Fatigue resistance is important. You don't want parts to break or bend like a lug nut on an airplane wing.

If we're talking about hip replacements, "... chrome is favoured if tensile and fatigue strength are required, titanium is favoured if load sharing with adjacent bone (uncemented prostheses) is required (titanium has a similar modulus to cortical bone)(4)." So it really depends on what you're going to do with that hip and whether you glue the prosthetic, or just jam it in there really tight.

Bo Jackson, cute enough to be a cyborg, and a super-human athlete.

The metal and the bone it's embedded in, making up the structure of an artificial joint, are able to withstand normal physical stresses. Professional athletes with joint replacements often end up with complications because they put super-human stress on their bodies. The metal may bend, the bone holding it may break, or the prosthetic starts to work its way lose. For this reason, RoboCop with his combination of exoskeleton and implanted sensory parts, Spooner and his entirely prosthetic limb, and Marcus with a full body endoskeleton are the creme de la creme of the Hollywood Cyborgs.

1. Which is why they use titanium or niobium in the skull.

2. This can lead to chronic inflammation and scarring in the area.

3. Women with breast implants do not qualify as cyborgs.

4. Page 394 from Imaging of the Hip and Bony Pelvis: techniques and applications, by Arthur Mark Davies, Karl J.Hohnson, Richard Wihehouse. Read it on Google books, otherwise it costs over $200!